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Image Search Results
Journal: Nature Communications
Article Title: Rapid amide ligation between α-halo acylsilanes and amines under aqueous conditions
doi: 10.1038/s41467-025-65617-y
Figure Lengend Snippet: LC-MS and SDS-PAGE gel analysis of proteins modified. Reaction of lysozyme ( A , B ), chymotrypsinogen A ( C ), myoglobin ( D ) and ribonuclease A ( E ) with α-halo acylsilanes in DMSO/NH 4 OAc (20 mM) = 4/1 at 25 °C for 1 h, independent replicates (n = 4) of SDS-PAGE gel analysis were performed in ( B ), with similar results. The mass spectrometry data had not been deconvoluted, and the number of added ions had been marked in the figure. (+1 mod. = singly modified protein, +2 mod. = doubly modified protein, etc.).
Article Snippet:
Techniques: Liquid Chromatography with Mass Spectroscopy, SDS Page, Modification, Mass Spectrometry